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The Muscular Dystrophies: From Genes to Therapies

RM Lovering, PT, PhD, is Research Associate, Department of Physiology, University of Maryland, School of Medicine, 685 W Baltimore St, Baltimore, MD 21201 (USA) (rlovering{at}som.umaryland.edu).
NC Porter, MD, is Assistant Professor, Department of Neurology, University of Maryland, School of Medicine
RJ Bloch, PhD, is Professor, Department of Physiology, University of Maryland, School of Medicine

Address all correspondence to Dr Lovering

The genetic basis of many muscular disorders, including many of the more common muscular dystrophies, is now known. Clinically, the recent genetic advances have improved diagnostic capabilities, but they have not yet provided clues about treatment or management. Thanks to better management strategies and therapeutic interventions, however, many patients with a muscular dystrophy are more active and are living longer. Physical therapists, therefore, are more likely to see a patient with a muscular dystrophy, so understanding these muscle disorders and their management is essential. Physical therapy offers the most promise in caring for the majority of patients with these conditions, because it is unlikely that advances in gene therapy will significantly alter their clinical treatment in the near future. This perspective covers some of the basic molecular biological advances together with the clinical manifestations of the muscular dystrophies and the latest approaches to their management.

Key Words: Muscular dystrophy • Skeletal muscle

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