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Effects of Exercise Training on Heart Rate Variability After Coronary Angioplasty

MW Tsai, PT, PhD, is Lecturer, Institute and Faculty of Physical Therapy, National Yang-Ming University, Taipei, Taiwan. This research was one part of her doctoral thesis in the Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
WC Chie, MD, PhD, is Professor, Department of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University
TBJ Kuo, MD, PhD, is Director and Professor, Institute of Neuroscience, Tsu Chi College of Medicine and Humanities, Hualien, Taiwan
MF Chen, MD, is Professor, Department of Internal Medicine, National Taiwan University Hospital
JP Liu, PhD, is Professor, Division of Biometry, Department of Agronomy, National Taiwan University
THH Chen, PhD, is Associate Professor, Department of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University
YT Wu, PT, PhD, is Director and Associate Professor, School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Rd, Taipei 10020, Taiwan

(ytw{at}ntu.edu.tw). Address all correspondence to Dr Wu

Background and Purpose. Cardiac autonomic dysfunction is associated with risk of restenosis and cardiovascular mortality in patients after percutaneous transluminal coronary angioplasty (PTCA). Analysis of heart rate variability (HRV) is an important, widely used method for assessing cardiac autonomic regulation. The purpose of this study was to investigate the effect of exercise training on HRV in subjects after PTCA.

Subjects and Methods. A total of 84 subjects who had undergone PTCA were recruited for this study. The subjects (age [mean±SD]=57.0±9.3 years) were randomly assigned to either an exercise group to undergo an 8-week outpatient exercise program or a control group to undergo usual care. Heart rate variability was measured for 5 minutes in the supine resting position at baseline and at the end of 8 weeks. Results. The parasympathetically modulated HRV of the subjects in the exercise group increased significantly compared with the HRV of subjects in the control group. The effects of training on HRV were independent of angioplasty type (balloon or stent) and were unrelated to whether the subjects had received previous PTCA. Discussion and Conclusion. Exercise training can increase parasympathetic modulation of cardiac function in people after they have undergone successful PTCA. Our results suggest that analysis of HRV can be extended to assess the effect of exercise training on cardiac autonomic dysfunction in people after coronary angioplasty.

Key Words: Exercise training • Heart rate variability • Percutaneous transluminal coronary angioplasty

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