HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) All Versions of this Article: ptj.20070017v1 87/11/1433    most recent Submit a response Alert me when this article is cited Alert me when Rapid Responses are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dusing, S. C Articles by Escolar, M. L Search for Related Content PubMed PubMed Citation Articles by Dusing, S. C Articles by Escolar, M. L Social Bookmarking                      What's this?

Gross Motor Development of Children With Hurler Syndrome After Umbilical Cord Blood Transplantation

SC Dusing, PT, PhD, is Assistant Professor, Department of Physical Therapy, School of Allied Health Professions, Virginia Commonwealth University, 1200 E Broad St, PO Box 980224, Richmond, VA 23298-0224 (USA).
DE Thorpe, PT, PhD, PCS, is Associate Professor, Center for Human Movement Science, Division of Physical Therapy, University of North Carolina, Chapel Hill, NC.
MD Poe, PhD, is Investigator, Frank Porter Graham Child Development Institute, University of North Carolina.
AE Rosenberg, PT, DrPH, is Assistant Professor, Center for Human Movement Science, Division of Physical Therapy, University of North Carolina, and Training Director, Center for the Study of Development and Learning, University of North Carolina.
VS Mercer, PT, PhD, is Associate Professor, Center for Human Movement Science, Division of Physical Therapy, University of North Carolina.
ML Escolar, MD, is Director, Program for Neurodevelopmental Function in Rare Disorders, Center for the Study of Development and Learning, University of North Carolina.

scdusing{at}vcu.edu

Background and Purpose: Little is known about the gross motor development of children with Hurler syndrome who have undergone umbilical cord blood transplantation (UCBT). The purpose of this study was to provide a description of gross motor development in children with Hurler syndrome after UCBT.

Subjects and Method: Longitudinal changes in gross motor abilities were documented on the gross motor subtests of the Peabody Developmental Motor Scales, second edition (PDMS-2) for 21 children with Hurler syndrome. Each child was assessed between 1 and 6 times after UCBT. The participants had a mean age (±SD) of 32.2±16.0 months at the time of the first assessment. The mean time (±SD) between UCBT and the first assessment was 16.2±16.5 months.

Results: The participants had marked gross motor delays, with a mean gross motor quotient 2 standard deviations below the mean for children who were developing typically. The rate of development differed between the subtests of the PDMS-2. The participants gained abilities at the slowest rate on the stationary subtest and at the fastest rate on the locomotor subtest.

Discussion and Conclusion: The participants had varying degrees of delay in different gross motor domains. While gaining new gross motor abilities over time, these children continued to have delays up to 48 months after UCBT. Physical therapists treating children with Hurler syndrome after UCBT should use assessment tools that will capture these differences and should individualize treatment plans accordingly. Additional research is needed to document the efficacy of physical therapy intervention with this population.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?